Safety of meloxicam oral provocation challenge in patients with NSAID reaction
نویسندگان
چکیده
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used drug groups worldwide, for their significant properties analgesic and anti-inflammatory. Induce a variety of adverse reactions, both type A (related to the effects of the drug) and type B (related to individual response). Although the mechanisms underlying the adverse effects remain unclear, inhibition of cyclooxygenase (COX) seems to be the most accepted explanation. For their significant analgesic, antipyretic and anti-inflammatory, constitute an essential medicine for the treatment of several diseases, making it imperative to find a safe alternative in patients who report a hypersensitivity reaction to AINE.
منابع مشابه
The safety of codeine in patients with non-steroidal anti-inflammatory drug hypersensitivity: a preliminary study.
BACKGROUND Drug provocation testing should be performed before safely prescribing an analgesic for patients that are hypersensitive to non-steroidal anti-inflammatory drugs (NSAIDs). Whether or not the direct histamine releasing effect of codeine renders it useful in NSAID-hypersensitive patients is unknown. This study aimed to determine if codeine could be recommended as a safe treatment optio...
متن کاملAre drug provocation tests still necessary to test the safety of COX-2 inhibitors in patients with cross-reactive NSAID hypersensitivity?
BACKGROUND COX-2 inhibitors are safe alternatives in patients with cross-reactive non-steroidal anti-inflammatory drug (NSAID) hypersensitivity. These drugs are recommended to these patients after negative drug provocation tests (DPTs). However, cumulative data on encouraging results about the safety of COX-2 inhibitors in the majority of these patients bring the idea as to whether a DPT is alw...
متن کاملSuccessful Diflunisal Desensitization in a Transthyretin Amyloidosis Patient with NSAID Allergy: A Case Report
Introduction: Amyloid diseases have been known to be hereditary, including transthyretin (TTR) amyloidosis where subunit protein mutations may occur in genes for TTR leading to the deposition of fibrils (low molecular weight subunits (5 to 25 kD) of proteins) in extracellular tissues. By reducing the formation of TTR amyloid, diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), has shown ...
متن کاملMeloxicam tolerance in hypersensitivity to nonsteroidal anti-inflammatory drugs.
BACKGROUND Patients with aspirin-sensitive respiratory and skin diseases experience cross reactions to all nonsteroidal anti-inflammatory drugs (NSAIDs) which inhibit cyclooxigenase (COX) enzymes. The need to identify an alternative drug that is safe and reliable is a common problem in clinical practice. OBJECTIVE The aim of this study was to test the tolerability of meloxicam in NSAID-sensit...
متن کاملThe Time Delay Between Drug Intake and Bronchospasm for Nonsteroidal Antiinflammatory Drugs Sensitive Patients
A study was performed to assess the time between drug intake and drug induced hypersensitivity reaction for patients sensitive to nonsteroidal antiinflammatory drugs (NSAID) in clinical patient history and after oral provocation tests. Drug hypersensitivity ENDA questionnaires were filled for the patients with suspected sensitivity to NSAID. Oral provocation tests were performed with suspected ...
متن کامل